期刊
JOURNAL OF ENDOVASCULAR THERAPY
卷 18, 期 4, 页码 601-606出版社
ALLIANCE COMMUNICATIONS GROUP DIVISION ALLEN PRESS
DOI: 10.1583/11-3469.1
关键词
abdominal aortic aneurysm; type II endoleak; aneurysm sac; pressure; stent-graft; migration; displacement force; experimental model; aneurysm model
Purpose: To evaluate the effects of type II endoleaks and sac pressurization on stent-graft displacement following endovascular aneurysm repair (EVAR). Methods: Experimental silicone infrarenal aneurysm (6-cm) models were treated'' with a Talent stent-graft deployed with 20-mm proximal and distal landing zones. Inflow and outflow vessels were created as part of the silicone model to control flow into the aneurysm sac. All aneurysm models were uniform, with a diameter neck of 31 mm, a neck length of 20 mm, and iliac artery diameters of 16 mm. The aortic model was secured in a water bath to a pulsatile pump under physiological conditions; the output phase ratio (%systole/%diastole) was set at 65/35 with a pump rate of 80 beats per minute. Commercially available bifurcated stent-grafts were then displaced in vitro utilizing a linear motion apparatus attached to a force gauge. The mean arterial pressure (MAP) and pulse pressure (PP) at the aortic inflow were 60.1+/-3.1 and 38.3+/-7.8 mmHg, respectively. Peak force to cause initial stent-graft migration with and without a type II endoleak was recorded and compared. Results: In aneurysm sacs with no endoleak, the MAP and sac PP were 32+/-6.4 and 6+/-1.3 mmHg, respectively (p<0.01). In aneurysm sacs with a type II endoleak, the MAP and sac PP were 54.1+/-9.7 and 16.1+/-4.1 mmHg, respectively (p<0.02). Peak force to initiate migration was 16.0+/-1.41 N (range 15-18) with no endoleak vs. 23.2+/-2.2 N (range 20-25) in those with a type IIa endoleak and 23.5+/-2.5 N (range 20-26) in those with a type IIb endoleak (p<0.001). Conclusions: Type II endoleaks are associated with a significantly increased sac pressure. Increased sac pressurization from type II endoleaks results in a significantly greater force to displace a stent-graft longitudinally. Type II endoleaks may therefore inhibit migration and offer a benefit following EVAR; however, clinical correlation of these results is required. J Endovasc Ther. 2011; 18: 601-606
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