期刊
OBESITY REVIEWS
卷 16, 期 7, 页码 607-619出版社
WILEY
DOI: 10.1111/obr.12286
关键词
Body weight gain; colorectal neoplasms; meta-analysis; observational studies
While the relationship between body mass index as an indicator of excess body weight and the risk of colorectal cancer (CRC) is well established, the association between body weight gain in adulthood and risk of CRC remains unresolved. We quantified this association in a meta-analysis of 12 observational studies published until November 2014 with a total of 16,151 incident CRC cases. Random effect models were used to obtain summary relative risks (RR) and 95% confidence intervals (95% CIs). Between-study heterogeneity was assessed using I-2 statistics. Overall, the summary RR (95% CI) was 1.22 (1.14-1.30) for high body weight gain (midpoint: 15.2kg) compared with stable weight (P for heterogeneity=0.182; I-2=21.2%). In a dose-response analysis, each 5kg weight gain was associated with a 4% (95% CI: 2%-5%) higher risk of CRC. The association persisted after adjustment for body weight at younger age and was present for both men and women, as well as for colon and rectal cancer. Differences by sex were detected for colon cancer (P for interaction=0.003, with higher risk for men than women), but not for rectal cancer (P for interaction=0.613). In conclusion, these data underscore the importance of body weight management from early adulthood onwards for the prevention of CRC development.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据