期刊
OBESITY REVIEWS
卷 16, 期 -, 页码 55-66出版社
WILEY
DOI: 10.1111/obr.12256
关键词
Brain energetics; monocarboxylate transporter; obesity
资金
- Swiss Fond National de Recherche Scientifique [31003A-140957]
- Societe Francophone du Diabete
- Swiss National Science Foundation (SNF) [31003A_140957] Funding Source: Swiss National Science Foundation (SNF)
Over the last two decades, several genes have been identified that appear to play a role in the regulation of energy homeostasis and body weight. For a small subset of them, a reduction or an absence of expression confers a resistance to the development of obesity. Recently, a knockin mouse for a member of the monocarboxylate transporter (MCT) family, MCT1, was demonstrated to exhibit a typical phenotype of resistance to diet-induced obesity and a protection from its associated metabolic perturbations. Such findings point out at MCTs as putatively new therapeutic targets in the context of obesity. Here, we will review what is known about MCTs and their possible metabolic roles in different organs and tissues. Based on the description of the phenotype of the MCT1 knockin mouse, we will also provide some insights about their putative roles in weight gain regulation.
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