期刊
OBESITY
卷 23, 期 7, 页码 1517-1524出版社
WILEY
DOI: 10.1002/oby.21130
关键词
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资金
- Ministry of Education, Culture, Sports, Science, and Technology of Japan [B26293139, B23390172, B20390182, 24659317, C20591737, B23390357, C20591774, B23390356, 23659580, A18689031, 24659666]
- Ministry of Health, Labour, and Welfare of Japan [H17-Men-eki-009, H18-Cho-ju-037, H20-Cho-ju-009, H23-Cho-ju-002, H25-Nanchi-to (Men)-005, H25-Cho-ju-007]
- Japan Osteoporosis Society
- Japanese Orthopaedic Association (JOA) [2006-1, 2010-2]
- National Science Foundation from the Ministry of Education, Culture, Sports, Science, and Technology of Japan [08033011-00262]
- Grants-in-Aid for Scientific Research [26293329, 23659580, 25670301, 24659317, 25670293, 26670307, 25460811, 15H04787, 24659666] Funding Source: KAKEN
ObjectiveTo determine whether 8-iso-prostaglandin F2 (8-iso-PGF2) is a reliable biomarker of the accumulation of metabolic risks [e.g., overweight, hypertension, impaired glucose tolerance (IGT), and dyslipidemia]. MethodsThis was a cross-sectional study of the baseline characteristics of a Japanese general population cohort study: Research on Osteoarthritis/Osteoporosis Against Disability (ROAD). Of 1,690 participants, 1,527 fulfilled all questionnaires and examinations. Free and conjugated urinary 8-iso-PGF2 levels and metabolic syndrome (MetS) components including blood pressure, HbA1c, total cholesterol, high-density lipoprotein cholesterol (HDL-C), and non-HDL-C were analyzed. The data were analyzed by ANCOVA, multiple regression analysis, and multinomial logistic analysis. Results8-iso-PGF2 was significantly associated with HbA1c and significantly inversely associated with total cholesterol and non-HDL-C. Notably, IGT with an HbA1c cut-off of 5.5% was significantly associated with 8-iso-PGF2 level in participants aged 50 years. Multinomial logistic regression analysis revealed 8-iso-PGF2 level was significantly associated with a greater number of MetS risks present; this association was stronger in younger participants. In participants aged 71 years, 8-iso-PGF2 was significantly associated with a greater number of MetS risks with higher IGT cut-offs. ConclusionsUrinary 8-iso-PGF2 can be a reliable marker of IGT and the accumulation of MetS risks, especially in younger people.
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