期刊
OBESITY
卷 23, 期 10, 页码 2053-2058出版社
WILEY
DOI: 10.1002/oby.21189
关键词
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资金
- National Heart, Lung, and Blood Institute [R01 HL094806, R01 HL118601]
- National Space Biomedical Research Institute through National Aeronautics and Space Administration Grant [NCC 9-58]
- National Institute of Diabetes and Digestive and Kidney Diseases [R01 DK099512]
- Clinical Translational Science Award from the National Center for Research Resources [UL1RR025758]
- NATIONAL CENTER FOR RESEARCH RESOURCES [UL1RR025758] Funding Source: NIH RePORTER
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL094806, R01HL118601] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK099512] Funding Source: NIH RePORTER
ObjectiveDiet-induced thermogenesis (DIT) is lower in the evening and at night than in the morning. This may help explain why meal timing affects body weight regulation and why shift work is a risk factor for obesity. The separate effects of the endogenous circadian systemindependent of behavioral cyclesand of circadian misalignment on DIT are unknown. MethodsThirteen healthy adults undertook a randomized crossover study with two 8-day laboratory visits: three baseline days followed either by repeated simulated night shifts including 12-h inverted behavioral cycles (circadian misalignment) or by recurring simulated day shifts (circadian alignment). DIT was determined for up to 114 min (hereafter referred to as early DIT) following identical meals given at 8AM and 8PM in both protocols. ResultsDuring baseline days, early DIT was 44% lower in the evening than morning. This was primarily explained by a circadian influence rather than any behavioral cycle effect; early DIT was 50% lower in the biological evening than biological morning, independent of behavioral cycle influences. Circadian misalignment had no overall effect on early DIT. ConclusionsThe circadian system plays a dominating role in the morning/evening difference in early DIT and may contribute to the effects of meal timing on body weight regulation.
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