期刊
OBESITY
卷 24, 期 1, 页码 51-59出版社
WILEY
DOI: 10.1002/oby.21317
关键词
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资金
- Deutsche Forschungsgemeinschaft, Obesity Mechanisms [SFB 1052, B01, B04]
- Federal Ministry of Education and Research (BMBF), Germany [FKZ: 01EO1501, FKZ: 82DZD00601]
- Kompetenznetz Adipositas (Competence network for Obesity) - Federal Ministry of Education and Research (German Obesity Biomaterial Bank) [FKZ 01GI1128]
- Helmholtz Alliance ICEMED-Imaging and Curing Environmental Metabolic Diseases, through the Initiative and Networking Fund of the Helmholtz Association
ObjectiveIndependent previous studies in both rodents and humans suggest a role of developmental genes in the origin of obesity and body fat distribution. Here, the hypothesis that human adipose tissue (AT) expression of the developmental genes homeobox transcription factors C9 (HOXC9) and C10 (HOXC10) is fat depot-specific and related to obesity-related traits was tested. MethodsIn 636 individuals, HOXC9 and HOXC10 mRNA expression was investigated in paired abdominal subcutaneous (SC) and omental AT samples in relation to a wide range of age, BMI, fat distribution, and metabolic parameters and in subfractions of isolated adipocytes and cells of the stromal vascular fraction (SVF). ResultsHOXC9 and HOXC10 mRNA expression is significantly higher in SC compared to omental AT. HOXC9 and HOXC10 mRNA expression significantly correlates with body fat mass, even after adjustment for age and gender. In smaller subgroups (depending on the availability of data), fat depot-related significant gender- and BMI-independent associations between HOXC9 and HOXC10 gene expression and parameters of glucose metabolism and AT biology were found (e.g., adipocyte size). ConclusionsTaken together, these data suggest that HOXC9 and HOXC10 may play an important role in the development of obesity, adverse fat distribution, and subsequent alterations in whole-body metabolism and AT function.
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