期刊
OBESITY
卷 24, 期 1, 页码 113-122出版社
WILEY
DOI: 10.1002/oby.21249
关键词
-
资金
- National Institute of Diabetes and Digestive and Kidney Diseases [U01-DK-66667, R01-DK-52401, DK-72526, DK-072526-04eS1]
- New York Obesity and Nutrition Research Center at St. Luke's Hospital (NYONRC) [DK-26687]
- Ferring Research Institute
- Columbia University
- CovX Pharmaceuticals
- National Center for Advancing Translational Sciences of NIH [UL1 TR000040]
- Columbia Liver Disease Research Fund
- NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES [UL1TR000040] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK072526, P30DK026687, U01DK066667, R01DK052401] Funding Source: NIH RePORTER
ObjectiveThis study examined whether changes in adipocyte long chain fatty acid (LCFA) uptake kinetics explain the weight regain increasingly observed following bariatric surgery. MethodsThree groups (10 patients each) were studied: patients without obesity (NO: BMI 24.22.3 kgm(-2)); patients with obesity (O: BMI 49.811.9); and patients classified as super-obese (SO: BMI 62.6 +/- 2.8). NO patients underwent omental and subcutaneous fat biopsies during clinically indicated abdominal surgeries; O were biopsied during bariatric surgery, and SO during both a sleeve gastrectomy and at another bariatric operation 16 +/- 2 months later, after losing 113 +/- 13 lbs. Adipocyte sizes and [H-3]-LCFA uptake kinetics were determined in all biopsies. ResultsV(max) for facilitated LCFA uptake by omental adipocytes increased exponentially from 5.1 +/- 0.95 to 21.3 +/- 3.20 to 68.7 +/- 9.45 pmol/sec/50,000 cells in NO, O, and SO patients, respectively, correlating with BMI (r=0.99, P<0.001). Subcutaneous results were virtually identical. By the second operation, the mean BMI (SO patients) fell significantly (P<0.01) to 44.4 +/- 2.4 kgm(-2), similar to the O group. However, V-max (40.6 +/- 11.5) in this weight-reduced group remained approximate to 2X that predicted from the BMI:V-max regression among NO, O, and SO patients. ConclusionsFacilitated adipocyte LCFA uptake remains significantly upregulated 1 year after bariatric surgery, possibly contributing to weight regain.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据