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The secreted Klotho protein restores phosphate retention and suppresses accelerated aging in Klotho mutant mice
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KIDNEY INTERNATIONAL (2013)
Fibroblast growth factor 23 is not associated with and does not induce arterial calcification
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The GH/IGF-1 axis in ageing and longevity
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Klotho Sensitizes Human Lung Cancer Cell Line to Cisplatin via PI3k/Akt Pathway
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Antibody-Mediated Activation of FGFR1 Induces FGF23 Production and Hypophosphatemia
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Arterial Klotho Expression and FGF23 Effects on Vascular Calcification and Function
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Fibroblast growth factor 23 enhances renal klotho abundance
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FGF23 acts directly on renal proximal tubules to induce phosphaturia through activation of the ERK1/2-SGK1 signaling pathway
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Soluble Klotho and Autosomal Dominant Polycystic Kidney Disease
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Relationship of low plasma klotho with poor grip strength in older community-dwelling adults: the InCHIANTI study
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EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY (2012)
Plasma soluble α-klotho protein levels in premature and term neonates: correlations with growth and metabolic parameters
Tania Siahanidou et al.
EUROPEAN JOURNAL OF ENDOCRINOLOGY (2012)
Can features of phosphate toxicity appear in normophosphatemia?
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JOURNAL OF BONE AND MINERAL METABOLISM (2012)
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Circulating αKlotho influences phosphate handling by controlling FGF23 production
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Protective effect of klotho protein against cisplatin ototoxicity in an auditory cell line
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Targeted Deletion of Klotho in Kidney Distal Tubule Disrupts Mineral Metabolism
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Vitamin D receptor agonists increase klotho and osteopontin while decreasing aortic calcification in mice with chronic kidney disease fed a high phosphate diet
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KIDNEY INTERNATIONAL (2012)
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KIDNEY INTERNATIONAL (2012)
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Expression of fgf23 and aklotho in developing embryonic tissues and adult kidney of the zebrafish, Danio rerio
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NEPHROLOGY DIALYSIS TRANSPLANTATION (2012)
Klotho modulates the stress response in human senescent endothelial cells
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REGULATION AND FUNCTION OF THE FGF23/KLOTHO ENDOCRINE PATHWAYS
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Relationship of Low-Circulating Anti-Aging'' Klotho Hormone with Disability in Activities of Daily Living among Older Community-Dwelling Adults
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REJUVENATION RESEARCH (2012)
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Reduced Klotho expression level in kidney aggravates renal interstitial fibrosis
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Circulating levels of soluble α-Klotho in patients with chronic kidney disease
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KL1 Internal Repeat Mediates Klotho Tumor Suppressor Activities and Inhibits bFGF and IGF-I Signaling in Pancreatic Cancer
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Klotho protein diminishes endothelial apoptosis and senescence via a mitogen-activated kinase pathway
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Fibroblast growth factors: from molecular evolution to roles in development, metabolism and disease
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The Cooperation of FGF Receptor and Klotho Is Involved in Excretory Canal Development and Regulation of Metabolic Homeostasis in Caenorhabditis elegans
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Klotho Inhibits Transforming Growth Factor-β1 (TGF-β1) Signaling and Suppresses Renal Fibrosis and Cancer Metastasis in Mice
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Circulating Levels of Soluble α-Klotho Are Markedly Elevated in Human Umbilical Cord Blood
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FGF23 induces left ventricular hypertrophy
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Klotho Deficiency Causes Vascular Calcification in Chronic Kidney Disease
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JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2011)
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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2010)
Association of the functional KL-VS variant of Klotho gene with early-onset ischemic stroke
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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2010)
Klotho: a novel phosphaturic substance acting as an autocrine enzyme in the renal proximal tubule
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Klotho protein deficiency and aging
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GERIATRICS & GERONTOLOGY INTERNATIONAL (2010)
A Consensus on Criteria for Cure of Acromegaly
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JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2010)
Klotho inhibits growth and promotes apoptosis in human lung cancer cell line A549
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Parathyroid cell resistance to fibroblast growth factor 23 in secondary hyperparathyroidism of chronic kidney disease
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Parathyroid Klotho and FGF-receptor 1 expression decline with renal function in hyperparathyroid patients with chronic kidney disease and kidney transplant recipients
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KIDNEY INTERNATIONAL (2010)
Depressed expression of Klotho and FGF receptor 1 in hyperplastic parathyroid glands from uremic patients
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KIDNEY INTERNATIONAL (2010)
Evidence against a direct role of klotho in insulin resistance
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PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2010)
Relevant use of Klotho in FGF19 subfamily signaling system in vivo
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Klotho is associated with VEGF receptor-2 and the transient receptor potential canonical-1 Ca2+ channel to maintain endothelial integrity
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Phosphate Levels and Cardiovascular Disease in the General Population
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In vivo genetic evidence for klotho-dependent, fibroblast growth factor 23 (Fgf23) -mediated regulation of systemic phosphate homeostasis
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FASEB JOURNAL (2009)
Klotho is a substrate for α-, β- and γ-secretase
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FEBS LETTERS (2009)
Klotho Gene Delivery Prevents the Progression of Spontaneous Hypertension and Renal Damage
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HYPERTENSION (2009)
Klotho Prevents Renal Calcium Loss
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Dietary Phosphorus Acutely Impairs Endothelial Function
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JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2009)
Reversal of mineral ion homeostasis and soft-tissue calcification of klotho knockout mice by deletion of vitamin D 1α-hydroxylase
Mutsuko Ohnishi et al.
KIDNEY INTERNATIONAL (2009)
FGF23 decreases renal NaPi-2a and NaPi-2c expression and induces hypophosphatemia in vivo predominantly via FGF receptor 1
Jyothsna Gattineni et al.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2009)
Role of the GH/IGF-1 axis in lifespan and healthspan: Lessons from animal models
Darlene E. Berryman et al.
GROWTH HORMONE & IGF RESEARCH (2008)
Morphological and biochemical signs of age-related neurodegenerative changes in klotho mutant mice
M. Shiozaki et al.
NEUROSCIENCE (2008)
Klotho: a tumor suppressor and a modulator of the IGF-1 and FGF pathways in human breast cancer
I. Wolf et al.
ONCOGENE (2008)
Removal of sialic acid involving Klotho causes cell-surface retention of TRPV5 channel via binding to galectin-1
Seung-Kuy Cha et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
A translocation causing increased α-Klotho level results in hypophosphatemic rickets and hyperparathyroidism
Catherine A. Brownstein et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
alpha-klotho: A regulator that integrates calcium homeostasis
Yo-ichi Nabeshima et al.
AMERICAN JOURNAL OF NEPHROLOGY (2008)
Insulin stimulates the cleavage and release of the extracellular domain of Klotho by ADAM10 and ADAM 17
Ci-Di Chen et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
The parathyroid is a target organ for FGF23 in rats
Iddo Z. Ben-Dov et al.
JOURNAL OF CLINICAL INVESTIGATION (2007)
Fibroblast growth factor-23 regulates parathyroid hormone and 1α-hydroxylase expression in cultured bovine parathyroid cells
Tijana Krajisnik et al.
JOURNAL OF ENDOCRINOLOGY (2007)
A homozygous missense mutation in human KLOTHO causes severe tumoral calcinosis
Shoji Ichikawa et al.
JOURNAL OF CLINICAL INVESTIGATION (2007)
Augmented Wnt signaling in a mammalian model of accelerated aging
Hongjun Liu et al.
SCIENCE (2007)
α-klotho as a regulator of calcium homeostasis
Akihiro Imura et al.
SCIENCE (2007)
Determination of the elimination half-life of fibroblast growth factor-23
Azarmindokht Khosravi et al.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2007)
Fibroblast growth factor (FGF)23 in patients with acromegaly
Nobuaki Ito et al.
ENDOCRINE JOURNAL (2007)
Relations of serum phosphorus and calcium levels to the incidence of cardiovascular disease in the community
Ravi Dhingra et al.
ARCHIVES OF INTERNAL MEDICINE (2007)
Ablation of vitamin D signaling rescues bone, mineral, and glucose homeostasis in Fgf-23 deficient mice
Martina Hesse et al.
MATRIX BIOLOGY (2007)
Correlation between hyperphosphatemia and type IINa-Pi cotransporter activity in klotho mice
Hiroko Segawa et al.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2007)
Anti-oxidative effect of Klotho on endothelial cells through cAMP activation
Hiromi Rakugi et al.
ENDOCRINE (2007)
Klotho converts canonical FGF receptor into a specific receptor for FGF23
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Klotho protein promotes adipocyte differentiation
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ENDOCRINOLOGY (2006)
Regulation of fibroblast growth factor-23 signaling by Klotho
H Kurosu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Effect of active acromegaly and its treatment on parathyroid circadian rhythmicity and parathyroid target-organ sensitivity
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JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2006)
Anti-apoptotic and anti-senescence effects of Klotho on vascular endothelial cells
M Ikushima et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2006)
Regulation of oxidative stress by the anti-aging hormone Klotho
M Yamamoto et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Relation between serum phosphate level and cardiovascular event rate in people with coronary disease
M Tonelli et al.
CIRCULATION (2005)
The β-glucuronidase klotho hydrolyzes and activates the TRPV5 channel
Q Chang et al.
SCIENCE (2005)
Suppression of aging in mice by the hormone Klotho
H Kurosu et al.
SCIENCE (2005)
KLOTHO genotype and cognitive ability in childhood and old age in the same individuals
IJ Deary et al.
NEUROSCIENCE LETTERS (2005)
Mutations that cause osteoglophonic dysplasia define novel roles for FGFR1 in bone elongation
KE White et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2005)
Secreted Klotho protein in sera and CSF: implication for post-translational cleavage in release of Klotho protein from cell membrane
A Imura et al.
FEBS LETTERS (2004)
Sinoatrial node dysfunction and early unexpected death of mice with a defect of klotho gene expression
K Takeshita et al.
CIRCULATION (2004)
FGF-23 is a potent regulator of vitamin D metabolism and phosphate homeostasis
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JOURNAL OF BONE AND MINERAL RESEARCH (2004)
FGF-23 transgenic mice demonstrate hypophosphatemic rickets with reduced expression of sodium phosphate cotransporter type IIa
T Shimada et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2004)
Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism
T Shimada et al.
JOURNAL OF CLINICAL INVESTIGATION (2004)
Immunohistochemical localization of Klotho protein in brain, kidney, and reproductive organs of mice
SA Li et al.
CELL STRUCTURE AND FUNCTION (2004)
Transgenic mice expressing fibroblast growth factor 23 under the control of the α1(I) collagen promoter exhibit growth retardation, osteomalacia, and disturbed phosphate homeostasis
T Larsson et al.
ENDOCRINOLOGY (2004)
Regulation of phosphate (Pi) transport and NaPi-III transporter (Pit-1) mRNA, in rat osteoblasts
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JOURNAL OF ENDOCRINOLOGY (2004)
Transgenic mice overexpressing human fibroblast growth factor 23 (R176Q) delineate a putative role for parathyroid hormone in renal phosphate wasting disorders
XY Bai et al.
ENDOCRINOLOGY (2004)
Human fibroblast growth factor-23 mutants suppress Na+ -dependent phosphate co-transport activity and 1α,25-dihydroxyvitamin D3 production
H Saito et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Klotho, a gene related to a syndrome resembling human premature aging, functions in a negative regulatory circuit of vitamin D endocrine system
H Tsujikawa et al.
MOLECULAR ENDOCRINOLOGY (2003)
Cognition impairment in the genetic model of aging klotho gene mutant mice:: a role of oxidative stress
T Nagai et al.
FASEB JOURNAL (2002)
Defects in growth and bone metabolism in klotho mutant mice are resistant to GH treatment
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JOURNAL OF ENDOCRINOLOGY (2002)
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S Ito et al.
BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION (2002)
In vivo klotho gene transfer ameliorates angiotensin II-induced renal damage
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HYPERTENSION (2002)
Mediation of unusually high concentrations of 1,25-dihydroxyvitamin D in homozygous klotho mutant mice by increased expression of renal 1α-hydroxylase gene
T Yoshida et al.
ENDOCRINOLOGY (2002)
Association of human aging with a functional variant of Klotho
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
IGF-I and GH stimulate Phex mRNA expression in lungs and bones and 1,25-dihydroxyvitamin D-3 production in hypophysectomized rats
E Zoidis et al.
EUROPEAN JOURNAL OF ENDOCRINOLOGY (2002)
Cloning and characterization of FGF23 as a causative factor of tumor-induced osteomalacia
T Shimada et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Severely reduced production of Klotho in human chronic renal failure kidney
N Koh et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2001)
Disruption of klotho gene causes an abnormal energy homeostasis in mice
K Mori et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2000)
Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23
KE White et al.
NATURE GENETICS (2000)
Molecular cloning and expression analyses of mouse ßklotho, which encodes a novel Klotho family protein
S Ito et al.
MECHANISMS OF DEVELOPMENT (2000)
Identification of a novel fibroblast growth factor, FGF-23, preferentially expressed in the ventrolateral thalamic nucleus of the brain
T Yamashita et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2000)
In vivo klotho gene delivery protects against endothelial dysfunction in multiple risk factor syndrome
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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2000)
Acromegaly in a hemophilic patient infected with the hepatitis C and human immunodeficiency viruses
C Schmid et al.
AMERICAN JOURNAL OF MEDICINE (2000)
The effect of GH replacement therapy on endothelial function and oxidative stress in adult growth hormone deficiency
LM Evans et al.
EUROPEAN JOURNAL OF ENDOCRINOLOGY (2000)
Establishment of the anti-klotho monoclonal antibodies and detection of klotho protein in kidneys
Y Kato et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2000)
Decreased insulin production and increased insulin sensitivity in the Klotho mutant mouse, a novel animal model for human aging
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METABOLISM-CLINICAL AND EXPERIMENTAL (2000)