期刊
OBESITY
卷 23, 期 6, 页码 1312-1319出版社
WILEY
DOI: 10.1002/oby.21079
关键词
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资金
- United States Army Medical Research and Materiel Command (MRMC)/Telemedicine and Advanced Technology Research Center (TATRC)
- Henry M. Jackson Foundation for the Advancement of Military Medicine [W81XWH-10-2-0080]
- Johns Hopkins Institute for Clinical and Translational Research (ICTR) - National Center for Advancing Translational Sciences (NCATS), a component of the National Institutes of Health (NIH) [UL1 TR 000424-06]
- NIH Roadmap for Medical Research
ObjectiveTo examine relationships between weight loss through changes in lifestyle and peripheral blood gene expression profiles. MethodsA prospective nonrandomized trial was conducted over 1 year in participants undergoing intensive lifestyle modification to reverse or stabilize progression of coronary artery disease. Cardiovascular risk factors, inflammatory biomarkers, and gene expression as a function of weight loss were assessed in 89 lifestyle participants and 71 retrospectively matched controls undergoing usual care. ResultsSubstantial weight loss (-15.23.8%) in lifestyle participants (n=33) was associated with improvement in selected cardiovascular risk factors and significant changes in peripheral blood gene expression from pre- to post-intervention: 132 unique genes showed significant expression changes (false discovery rate corrected P-value <0.05 and fold-change 1.4). Altered molecular pathways were related to immune function and inflammatory responses involving endothelial activation. In contrast, participants losing minimal weight (-3.1 +/- 2.5%, n=32) showed only minor changes in cardiovascular risk factors and markers of inflammation and no changes in gene expression compared to non intervention controls after 1 year. ConclusionsWeight loss (10%) during lifestyle modification is associated with down-regulation of genetic pathways governing interactions between circulating immune cells and the vascular endothelium and may be required to successfully reduce CVD risk.
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