Comparable effects of moderate intensity exercise on changes in anorectic gut hormone levels and energy intake to high intensity exercise

There is growing interest in the effects of exercise on plasma gut hormone levels and Subsequent energy intake (EI) but the effects of mode and exercise intensity oil anorectic hormone profiles oil subsequent El remain to be elucidated. We aimed to investigate whether circulating peptide YY3-36 (PYY3-36) and glucagon-like peptide-1 (GLP-1 or GCG as listed in the HUGO Database) levels depend on exercise intensity; which could affect subsequent El. Ten young male subjects (mean +/- S.D., age: 23.4 +/- 4.3 years, body mass index: 22.5 +/- 1.0 kg/m(2), and maximum oxygen uptake (VO2 max) 45.9 +/- 8.5 ml/kg per min) received a standardized breakfast, which was followed by constant cycling exercise at 75% VO2 max (high intensity session), 50% VO2 max (moderate intensity session), or rest (resting session) for 30 min. At lunch, a test meal was presented, and El was calculated. Blood samples were obtained during three sessions for Measurements of glucose, insulin, PYY3-36, and GLP-1, which includes GLP-1 (7-36) amide and GLP-1 (9-36) amide. Increases in blood PYY3-36 levels were dependent oil the exercise intensity (effect of session: P<0.001 by two-way ANOVA), whereas those in GLP-1 levels were similar between two different exercise sessions. Of note, increase in area under the Curve values for GLP-1 levels was negatively correlated with decrease in the El in each exercise session (high: P<0.001, moderate: P=0.002). The present findings raise the possibility that each gut. horn-lone exhibits its specific blood kinetics in response to two different intensities of exercise stimuli and might play differential roles in regulation of El after exercise. Journal of Endocrinology (2009) 203, 357-364