期刊
JOURNAL OF ENDOCRINOLOGY
卷 202, 期 2, 页码 191-198出版社
BIOSCIENTIFICA LTD
DOI: 10.1677/JOE-09-0056
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资金
- Wellcome Trust [081922/Z/07/Z]
- Wellcome Trust [081922/Z/07/Z] Funding Source: Wellcome Trust
Ghrelin, a hormone primarily produced by the stomach, has a wide range of metabolic and non-metabolic effects. It also stimulates food intake through activation of various hypothalamic and brain stem neurons. A series of recent studies have explored the intracellular mechanisms of the appetite-inducing effect of ghrelin in the hypothalamus, shedding light on the intricate mechanisms of appetite regulation. AMP-activated protein kinase (AMPK) is a key metabolic enzyme involved in appetite regulation. Calmodulin kinase kinase 2 (CaMKK2) has been identified as an upstream kinase of AMPK and a key mediator in the effect of ghrelin on AMPK activity. The fatty acid pathway, hypothalamic mitochondrial respiration, and uncoupling protein 2 have been outlined as downstream tat-gets of AMPK and mediators of ghrelin's appetite stimulating effect. This short overview summarises the present data in this field. Journal of Endocrinology (2009) 202, 191-198
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