Hedgehog signalling in endocrine development and disease

The hedgehog (Hh) pathway is an evolutionarily conserved signalling pathway that is required for many essential tissue cellular properties such as patterning fields of cells or and regulating cell differentiation and proliferation. Disruption of the pathway results in serious pathologies. In this review, we provide an update on recent finding,, in the field of vertebrate Hh signalling and also describe contributions of Hh signalling to the development, maintenance and pathology of endocrine tissues.