期刊
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
卷 33, 期 6, 页码 422-433出版社
SPRINGER
DOI: 10.1007/BF03346615
关键词
Antioxidants; coenzyme Q(10); oxidative stress; pituitary
Oxidative stress, a condition defined as unbalancing between production of free radicals and antioxidant defenses, is an important pathogenetic mechanism in different diseases. Despite the abundant literature, many aspects of hormone role in regulating antioxidant synthesis and activity still remain obscure. Therefore, we reviewed experimental data, in vivo and in vitro, about the effects of the different pituitary-dependent axes on antioxidant levels, trying to give a broad view from hormones which also have antioxidant properties to the classic antioxidants, from the lipophilic antioxidant Coenzyme Q(10), strictly related to thyroid function, to total antioxidant capacity, a measure of non-protein non-enzymatic antioxidants in serum and other biological fluids. Taken together, these data underline the importance of oxidative stress in various pituitary-dependent disorders, suggesting a possible clinical usefulness of antioxidant molecules. (J. Endocrinol. Invest. 33: 422-433, 2010) (C)2010, Editrice Kurtis
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