期刊
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
卷 25, 期 4, 页码 376-381出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.numecd.2014.12.008
关键词
Carotenoids; Cohort study; Diet; Type 2 diabetes; beta-carotene; alpha-carotene
资金
- European Commission
- Dutch Ministry of Public Health, Welfare and Sports (VWS)
- Netherlands Cancer Registry (NKR)
- Dutch Prevention Funds
- Dutch ZON (Zorg Onderzoek Nederland)
- World Cancer Research Fund (WCRF) (The Netherlands)
Background and aims: Carotenoids may reduce diabetes risk, due to their antioxidant properties. However, the association between dietary carotenoids intake and type 2 diabetes risk is still unclear. Therefore, the objective of this study was to examine whether higher dietary carotenoid intakes associate with reduced type 2 diabetes risk. Methods and results: Data from 37,846 participants of the European Prospective Investigation into Cancer and Nutrition-Netherlands study were analyzed. Dietary intakes of beta-carotene, alpha-carotene, beta-cryptoxanthin, lycopene, lutein & zeaxanthin and the sum of these carotenoids were assessed using a validated food frequency questionnaire. Incident type 2 diabetes was mainly self-reported, and verified against general practitioner information. Mean +/- SD total carotenoid intake was 10 + 4 mg/day. During a mean +SD follow-up of 10 + 2years, 915 incident cases of type 2 diabetes were ascertained. After adjustment for age, sex, diabetes risk factors, dietary intake, waist circumference and BMI, higher beta-carotene intakes associated inversely with diabetes risk [Hazard Ratio quartile 4 versus quartile 1 (HRQ4): 0.78 (95%CI:0.64,0.95), P-linear trend 0.01]. For alpha-carotene, a borderline significant reduced risk was observed, with a HRQ4 of 0.85 (95%CI:0.70,1.03), and P-linear trend 0.05. beta-cryptoxanthin, lycopene, lutein & zeaxanthin, and the sum of all carotenoids did not associate with diabetes risk. Conclusions: This study shows that diets high in beta-carotene and alpha-carotene are associated with reduced type 2 diabetes in generally healthy men and women. (C) 2015 Elsevier B.V. All rights reserved.
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