期刊
NUTRITION & METABOLISM
卷 12, 期 -, 页码 -出版社
BIOMED CENTRAL LTD
DOI: 10.1186/s12986-015-0034-1
关键词
Energy expenditure; Physical activity; Body composition; Adipose tissue; Glucose metabolism; Fatty acid metabolism
资金
- Maastricht University
Background: Energy restriction causes adaptations in energy expenditure (total-, TEE; resting-, REE; activity induced-, AEE). Objective: To determine if changes in the levels of proteins involved in adipocyte glucose and fatty acid metabolism as indicators for energy deficiency are related to adaptations in energy expenditure during weight loss. Methods: Forty-eight healthy subjects (18 men, 30 women), mean +/- SD age 42 +/- 8 y and BMI 31.4 +/- 2.8 kg/m(2), followed a very low energy diet for 8 wk. Protein levels of fatty acid binding protein 4 (FABP4), fructosebisphosphate aldolase C (AldoC) and short chain 3-hydroxyacyl-CoA dehydrogenase (HADHsc) (adipose tissue biopsy, western blot), TEE (doubly labeled water), REE (ventilated hood), and AEE were assessed before and after the 8-wk diet. Results: There was a positive correlation between the decrease in AldoC and the decrease in TEE (R = 0.438, P < 0.01) and the decrease change in AEE (R = 0.439, P < 0.01). Furthermore, there was a negative correlation between the increases in HADHsc and the decrease in REE (R = 0.343, P < 0.05). Conclusion: The decrease in AldoC correlated with the decrease in AEE, which may be explained by a decreased glycolytic flux. Additionally, the change in HADHsc, a crucial enzyme for a step in beta-oxidation, correlated with the adaptation in REE.
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