期刊
NUTRITION
卷 31, 期 2, 页码 406-408出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.nut.2014.08.001
关键词
Parkinson's disease; Clinical assessment; Biomarkers; Oxidative stress; Vitamin C
资金
- Japanese Ministry of Health, Labor, and Welfare [242 20 501]
- Grants-in-Aid for Scientific Research [15K08924, 15J10190] Funding Source: KAKEN
Objectives: Vitamin C is a major antioxidant and also is known as a neuromodulator in dopaminergic neurons. The aim of this study was to investigate the association between lymphocyte and plasma vitamin C levels in various stages of Parkinson's disease (PD). Methods: Sixty-two individuals with PD (age 71 +/- 8.8 y [mean +/- SD]) being treated at Shizuoka General Hospital from December 2007 to August 2013 were consecutively recruited. PD severity was classified using the Hoehn-Yahr scale for staging PD. Fasting blood samples were collected, and plasma and lymphocyte vitamin C levels were measured. The association between PD severity and vitamin C levels was estimated by ordinal logistic regression with confounding variables. Results: The distribution of Hoehn-Yahr stages in patients was as follows: stage I, 7; II, 28; III, 16; and IV, 11. Lymphocyte vitamin C levels in patients with severe PD were significantly lower (odds ratio [OR], 0.87; 95% confidence interval [Cl], 0.80-0.97; P < 0.01) compared with those at less severe stages. Plasma vitamin C levels also tended to be lower in patients with severe PD; however, this was not significant (OR, 0.98; 95% CI, 0.96-1.00; P = 0.09). Conclusions: Our findings suggest that lymphocyte vitamin C levels in the peripheral blood may be a potentially useful biomarker for the progression of PD. (C) 2015 Elsevier Inc. All rights reserved.
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