期刊
JOURNAL OF ELECTRON MICROSCOPY
卷 59, 期 2, 页码 181-183出版社
OXFORD UNIV PRESS
DOI: 10.1093/jmicro/dfp048
关键词
hypertrophic cardiomyopathy; heart failure; autophagy; endomyocardial biopsy; pathology
类别
Endomyocardial biopsy of a patient in transition stage from hypertrophic cardiomyopathy to heart failure was investigated. The tissue showed hypertrophy, atrophy of myocytes and an increased amount of fibrosis. In addition, numerous cardiomyocytes revealed ubiquitin positive inclusions. Ultrastructural analysis indicated that cardiomyocytes contained typical autophagic vacuoles including mitochondria, glycogen granules, degraded remnants and myelin structures. The most obvious ultrastructural finding was the presence of amorphous plaques and tubulofilamentous inclusions. Such ultrastructural abnormalities allow us to conclude that degeneration of myocardial cells by autophagy mechanisms leads to cardiomyocyte death, loss and heart failure.
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