期刊
JOURNAL OF DRUG TARGETING
卷 22, 期 4, 页码 295-303出版社
INFORMA HEALTHCARE
DOI: 10.3109/1061186X.2013.878940
关键词
Gene therapy; molecular imaging; radionuclide; reporter gene; theranostics; transcriptional targeting; transductional targeting
资金
- Medical Cluster R&D Support Project of Daegu Gyeongbuk Medical Innovation Foundation
- Republic of Korea (2013) [A111345, A091224]
- National Nuclear R& D Program through the National Research Foundation of Korea (NRF)
- Ministry of Education, Science and Technology [2012M2A2A7014020, 2009-0078234]
- Korea Healthcare technology R D Project
- Ministry for Health, Welfare Family Affairs
- Korea Health Promotion Institute [HT13C0006010014] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- National Research Foundation of Korea [2012M2A2A7014020, 2009-0078234] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Radionuclide-based theranostic strategy has been widely used in diagnosis and treatment of patients with hyperthyroidism or differentiated thyroid cancer for a long time, and sodium iodide symporter gene is the radionuclide-based reporter gene used in theranostics. Theranostics, which is a promising approach, offering the ideal combination of accurate diagnosis and successful therapy in various clinical fields, is expected to become a key area of personalized medicine. Rapid advancements in biotechnologies using theranostic reporter genes and theranostic radiochemistry have led to development of the concept of theranostics using radionuclide-based imaging reporter genes; the theranostic approach is almost ready for application in a limited arena of clinics. In order to fulfill both the diagnostic and therapeutic purposes, theranostics with radionuclide-based imaging reporter requires use of successful combinations of various components, such as radionuclide-based reporter genes, promoters/enhancers that regulate expression of reporter genes, delivery vectors/vehicles, imaging or therapeutic probes and prodrugs, transductional and transcriptional targeting strategies, transgene amplification systems, etc. In this review, overview and recent updates on theranostics using radionuclide-based imaging reporter genes will be discussed.
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