期刊
JOURNAL OF DRUG TARGETING
卷 16, 期 7-8, 页码 601-604出版社
INFORMA HEALTHCARE
DOI: 10.1080/10611860802228954
关键词
liposome; doxorubicin; anti-cancer monoclonal antibody; prostate cancer; tumor targeting
资金
- NATIONAL CANCER INSTITUTE [R01CA087617] Funding Source: NIH RePORTER
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL055519] Funding Source: NIH RePORTER
- NCI NIH HHS [CA 87617] Funding Source: Medline
- NHLBI NIH HHS [R01 HL55519] Funding Source: Medline
Long-circulating liposomes loaded with doxorubicin (Dox) were additionally modified with the prostate cell-specific monoclonal antibody 5D4 (mAb 5D4). The resultant Dox-loaded 5D4-immunoliposomes specifically recognized prostate cancer cell lines of several different types expressing the mAb 5D4 antigen, PSMA, and significantly enhanced cytotoxicity toward these cells compared with the non-targeted Dox-liposomes in vitro while no increased toxicity was observed toward non-prostate (lung) cancer cell line.
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