期刊
JOURNAL OF DRUG TARGETING
卷 16, 期 5, 页码 329-356出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/10611860801969616
关键词
polymer; dendrimer; macromolecular architecture; tumor targeting; gene delivery; drug delivery
The use of polymeric carriers for drug delivery has become increasingly popular because of the ability to easily tune the physical and biological properties of macromolecules. With the growing commercial accessibility of branched and dendritic polymers, their incorporation into polymeric carriers is being explored with increased frequency. However, while a handful of systematic studies have explored the use of branched macromolecules for drug delivery, the role of polymer architecture in optimizing the polymeric carriers is not yet fully understood. Herein, the authors summarize the effect that architecture has on the basic physical properties of polymers, and review our preliminary understanding of the architectural effects on polymer-assisted drug delivery.
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