期刊
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
卷 24, 期 3, 页码 293-299出版社
EDITIONS SANTE
DOI: 10.1016/S1773-2247(14)50048-2
关键词
Microneedle; Pore size; Dimernsion; Recovery; Microchannels; Laser
Transdermal therapies have been known and used by many cultures over the centuries. The modern age of transdermal drug delivery started with the marketing of Transderm Scop in 1979 as a scopolamine patch for the treatment of motion sickness, nausea and vomiting. Since 1997. transdermal drug delivery companies have aligned with life science and biopharmaceutical industries, to deliver large molecules, peptides and proteins, i.e. insulin, calcitonin, PTH (1-34), etc. Strategies and technologies have been developed for skin pretreatment or continuous use, in order to accomplish large molecule delivery. So far, the most effective strategy for overcoming the skin's barrier properties has been to focus on the creation of micropores in the stratum corneum. Microchannels or micropores can be created by external means such as microneedles, ultrasound, electroporation. radiofrequency and laser. Strategies and methods are now being developed to characterize micropores and understand their viability. Additionally, approaches to enhancing micropore lifetime are being investigated. The key to future successes in transdermal drug delivery of large molecules, especially biopharmaceuticals, will be the understanding and maintenance of skin micropores generated by microneedle pretreatment or other external physical techniques.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据