期刊
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
卷 19, 期 1, 页码 3-14出版社
ELSEVIER
DOI: 10.1016/S1773-2247(09)50001-9
关键词
Anti-viral; Conjugate; Fosamprenavir; HIV; Nanocarrier; Prodrug; Targeted drug delivery; Tenofovir disoproxil fumarate
资金
- NIH MERIT Award [AI51214]
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R37AI051214, R01AI051214] Funding Source: NIH RePORTER
Despite the wide variety of highly potent anti-HIV drugs that have been developed and made available in clinical practice over the years, eradication of HIV infection has not been achieved. Currently, HIV infection and AIDS are thought to be chronically treatable. HIV attacks host immune cells namely macrophages and CD4(+) T-cells and sequesters itself into sanctuary and reservoir sites such as the lymphoid tissues, testes, and brain. Initial drug delivery efforts with prodrugs and drug conjugates focused on improving the physiochemical (i.e. solubility), biopharmaceutic (i.e. absorption, metabolism), and pharmacokinetic (i.e. blood concentrations) properties of the parent drugs. Eradicating HIV, however, will require advanced drug delivery approaches in order to access and maintain effective drug concentrations for prolonged periods of time in sanctuary sites. The current review discusses prodrug/conjugate efforts, clinical successes and describes drug delivery challenges and approaches for eradicating HIV infection.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据