期刊
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
卷 19, 期 6, 页码 391-399出版社
ELSEVIER
DOI: 10.1016/S1773-2247(09)50082-2
关键词
Molecular recognition; Hydrogels; Angiotensin; Drug delivery recognitive system
资金
- National Science Foundation
Molecularly imprinted polymer carriers have a large potential for use as drug delivery systems using the recognitive mechanism as the trigger for the release of a therapeutic compound in response to e external stimuli or even as the sensing element to give feedback as part of a biological sensor. We discuss the principles of this process using a type of molecular imprinting termed configurational biomimesis which produces polymeric surfaces or polymeric recognitive networks that have three dimensional, stereospecific binding micro- and nanocavities based on a given template molecule. The news synthetic recognitive biomaterials are designed to mimic biological recognition. which is ultimately an improvement over using expensive and unstable naturally, occurring biological macromolecules and ligands. We show ail application to the recognition of angiotensin II, a biomarker of high blood pressure.
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