期刊
JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY
卷 35, 期 5, 页码 619-640出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/01932691.2013.802242
关键词
Atenolol; transdermal drug delivery; principal component analysis; D-optimal design; thickening agents; microemulsion; quality by design
The objective of the present investigation was to develop microemulsion-based transdermal systems of highly water soluble drug, Atenolol, by quality by design technique. Atenolol-loaded W/O microemulsions were optimized using D-optimal design with concentrations of oil, surfactants mixture, and water as independent variables, which was converted into microemulsion-based gel (MBG). The results of in vitro permeation of the optimized batch of Atenolol-loaded MBG revealed significant increase in permeability parameters as compared to its convention gel. All results suggested suitability of W/O type MEs as carriers for transdermal delivery of highly water soluble drug, Atenolol.
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