期刊
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
卷 178, 期 4, 页码 810-830出版社
HUMANA PRESS INC
DOI: 10.1007/s12010-015-1911-9
关键词
Adenosine monophosphate-activated protein kinase; Drug design; Computer-aided drug design
资金
- School of Health Sciences, University of KwaZulu-Natal, Westville, Durban, South Africa
Adenosine monophosphate-activated protein kinase (AMPK) is viewed as a privileged therapeutic target for several diseases such as cancer, diabetes, inflammation, obesity, etc. In addition, AMPK has entered the limelight of current drug discovery with its evolution as a key metabolic regulator. AMPK also plays a key role in the maintenance of cellular energy homeostasis. Structurally, AMPK is a heterotrimeric protein, which consists of three protein subunits (alpha, beta, and gamma). The crystal structure of AMPK was solved, and several computational studies including homology modeling, molecular docking, molecular dynamics, and QSAR have been reported in order to explore the structure and function of this diverse therapeutic target. In this review, we present a comprehensive up-to-date overview on the computational and molecular modeling approaches that have been carried out on AMPK in order to understand its structure, function, dynamics, and its drug binding landscape. Information provided in this review would be of great interest to a wide pool of researchers involved in the design of new molecules against various diseases where AMPK plays a predominant role.
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