期刊
JOURNAL OF DIGESTIVE DISEASES
卷 13, 期 1, 页码 2-9出版社
WILEY-BLACKWELL
DOI: 10.1111/j.1751-2980.2011.00550.x
关键词
dysplasia; gastric carcinoma; intestinal metaplasia; precancerous cascade
资金
- U.S. National Cancer Institute [P01-CA28842]
Invasive gastric carcinoma is preceded by a cascade of precancerous lesions. The first recognized histologic change is active chronic inflammation, which may persist as such: non-atrophic chronic gastritis (no gland loss), or advance to multifocal atrophic gastritis (MAG), the first real step in the precancerous cascade. The following steps are: intestinal metaplasia (first complete and then incomplete); dysplasia, first low grade and then high grade (equivalent to carcinoma in situ). The following step is invasive carcinoma, which is thought to be associated with degradation of the intercellular matrix.
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