期刊
NUCLEIC ACIDS RESEARCH
卷 44, 期 D1, 页码 D1018-D1022出版社
OXFORD UNIV PRESS
DOI: 10.1093/nar/gkv1288
关键词
-
资金
- U.S. National Cancer Institute (NCI
- MD Anderson TCGA Genome Data Analysis Center) [CA143883, CA083639]
- Cancer Prevention Research Institute of Texas (CPRIT) [RP130397]
- Mary K. Chapman Foundation
- Michael & Susan Dell Foundation
- MD Anderson Cancer Center Support Grant [P30 CA016672]
TCGA's RNASeq data represent one of the largest collections of cancer transcriptomes ever assembled. RNASeq technology, combined with computational tools like our SpliceSeq package, provides a comprehensive, detailed view of alternative mRNA splicing. Aberrant splicing patterns in cancers have been implicated in such processes as carcinogenesis, de-differentiation and metastasis. TCGA SpliceSeq (http://bioinformatics.mdanderson.org/TCGASpliceSeq) is a web-based resource that provides a quick, user-friendly, highly visual interface for exploring the alternative splicing patterns of TCGA tumors. Percent Spliced In (PSI) values for splice events on samples from 33 different tumor types, including available adjacent normal samples, have been loaded into TCGA SpliceSeq. Investigators can interrogate genes of interest, search for the genes that show the strongest variation between or among selected tumor types, or explore splicing pattern changes between tumor and adjacent normal samples. The interface presents intuitive graphical representations of splicing patterns, read counts and various statistical summaries, including percent spliced in. Splicing data can also be downloaded for inclusion in integrative analyses. TCGA SpliceSeq is freely available for academic, government or commercial use.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据