期刊
JOURNAL OF DIABETES AND ITS COMPLICATIONS
卷 27, 期 6, 页码 548-552出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jdiacomp.2013.07.005
关键词
Chronic kidney disease; Type 2 DM; Oxidative stress; Inflammation
资金
- Indian Council of Medical Research
- University college of medical sciences, New Delhi
Chronic kidney disease (CKD) is a major cause of morbidity and mortality worldwide. It results from diverse etiologies, diabetes being a frontrunner amongst them. Type 2 diabetes mellitus (DM) is being increasingly recognized as a proinflammatory state with increased oxidative stress which enormously increases the risk of micro and macro vascular diseases. This study was planned to explore the possible association between tumor necrosis factor-alpha (TNF-alpha), urinary monocyte chemoattractant protein-1 (uMCP-1), high-sensitivity C-reactive protein (hsCRP) and parameters of oxidative stress in patients with Type 2 diabetes mellitus (DM) and diabetic chronic kidney disease (DM-CKD). Fifty patients each were recruited in DM, DM-CKD and healthy control groups. Plasma TNF-alpha, hsCRP and uMCP-1 levels as inflammatory mediators were measured by ELISA, reduced glutathione (GSH), ferric reducing ability of plasma (FRAP) as parameters of antioxidant activity and malondialdehyde. (MDA) as marker of oxidative stress, were measured spectrophotometrically. Plasma INF-alpha, hsCRP and uMCP-1 were significantly higher in DM-CKD compared to DM and healthy controls. Lipid peroxidation, measured as MDA was significantly higher in patients with DM-CKD as compared to patients with DM and healthy controls. Further, antioxidant capacity of blood measured as FRAP and GSH was found to be significantly lower in patients with DM and DM-CKD as compared to healthy controls (p < 0.001). Plasma TNF-alpha and uMCP-1 showed a significant positive correlation with HbA(1c), (r = 0.441, 0.643), hsCRP (r = 0.400, 0.584) and MDA (r = 0.423, 0.759) and significant negative correlation with GSH (R = -0.370, -0.800) and FRAP (r = -0.344, -0.684) Increased inflammatory markers viz. TNF-alpha, hsCRP and uMCP-1 and markers of oxidative stress i.e. increased MDA and decreased GSH and FRAP in DM-CKD suggest an important role of inflammation and oxidative stress in the pathogenesis of renal damage in diabetic patients. (C) 2013 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据