期刊
JOURNAL OF DERMATOLOGY
卷 42, 期 2, 页码 166-170出版社
WILEY
DOI: 10.1111/1346-8138.12739
关键词
fungal microbiome; Malassezia; psoriasis; pyrosequencing
类别
资金
- Grants-in-Aid for Scientific Research [25460226, 25461695] Funding Source: KAKEN
The skin surface is colonized by a wide variety of fungi and bacteria. While many of these organisms, including Malassezia, Candida, Streptococcus and Staphylococcus species, are associated with provocation and/or exacerbation of psoriasis, a detailed analysis of the cutaneous fungal microbiome in psoriatic patients has yet to be performed. To identify the disease-specific fungal microbiota on psoriatic scale samples, fungal rRNA gene sequences from 12 psoriatic patients and 12 healthy controls were analyzed by pyrosequencing. A total of 317806 high-quality sequences were obtained, representing 142 genera. Malassezia species were the most abundant sequences in both populations (46.9 +/- 14.0% in psoriasis vs 76.0 +/- 14.6% for healthy controls). Principal coordinate analysis revealed that the fungal microbiomes were independent. Although an association between the cutaneous fungal microbiome and psoriasis has yet to be established, our data indicate that the microbiome in patients with psoriasis is independent of that in healthy controls.
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