期刊
JOURNAL OF DERMATOLOGICAL SCIENCE
卷 59, 期 1, 页码 1-6出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.jdermsci.2010.05.001
关键词
MDSC; Tumorimmunology; Cancer
类别
Myeloid derived suppressor cells (MDSCs) comprise a phenotypically heterogeneous population of cells, which can be found in tumor-bearing mice and in patients with cancer. MDSCs play a central role in the induction of peripheral tolerance. Together with regulatory T cells (Tregs) they promote an immunosuppressive environment in tumor-bearing hosts. The phenotype of MDSCs differs in humans and mice, and the exact mechanisms of their suppressive function are still controversially discussed. In summary, MDSCs are a group of phenotypically heterogeneous cells of myeloid origin that have common biological activities. In this review, we discuss the definition of MDSCs, the proposed mechanisms of expansion and the recruitment and activation of MDSCs, as well as their biological activities in tumor-bearing hosts to assess the potential therapeutic applications. (C) 2010 Japanese Society for Investigative Dermatology. Published by Elsevier Ireland Ltd. All rights reserved.
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