期刊
JOURNAL OF DERMATOLOGICAL SCIENCE
卷 49, 期 1, 页码 7-19出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.jdermsci.2007.09.009
关键词
allergy; asthma; immunosuppression; IL-10; innate immunity
类别
资金
- NATIONAL CANCER INSTITUTE [R01CA072074] Funding Source: NIH RePORTER
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [P50HL067674, P01HL067674] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI023990, R01AI070813, R37AI023990] Funding Source: NIH RePORTER
- NCI NIH HHS [R01 CA072074-21, CA72074, R01 CA072074-16, R01 CA072074, R01 CA072074-19, R01 CA072074-23, R01 CA072074-17, R01 CA072074-15, R01 CA072074-22A1, R01 CA072074-24, R01 CA072074-18, R01 CA072074-20] Funding Source: Medline
- NHLBI NIH HHS [P50 HL067674-050002, P50 HL067674-02, HL67674, P50 HL067674, P01 HL067674, P50 HL067674-05, P50 HL067674-030002, P50 HL067674-03, P50 HL067674-020002, P50 HL067674-040002, P50 HL067674-04] Funding Source: Medline
- NIAID NIH HHS [R37 AI023990-16, R01 AI070813-04, R37 AI023990-18, R37 AI023990-13, R37 AI023990-19, AI23990, R37 AI023990-14, R01 AI023990, R01 AI070813, R37 AI023990, R37 AI023990-17, R37 AI023990-15, AI070813] Funding Source: Medline
The possible roles of mast cells in heath and disease have been a topic of interest for over 125 years. Many adaptive or pathological processes affecting the skin or other anatomical sites have been associated with morphological evidence of mast cell activation, and/or with changes in mast cell numbers or phenotype. Such observations, taken together with the known functions of the diverse mediators, cytokines and growth factors which can be secreted by mast cells, have suggested many potential functions for mast cells in health and disease. Definitively identifying the importance of mast cells in biological responses in humans is difficult. However, mutant mice which are profoundly mast cell-deficient, especially those which can undergo engraftment with wild-type or genetically altered mast cells, provide an opportunity to investigate the importance of mast cells, and specific mast cell functions or products, in various adaptive or pathological responses in mice. Such work has shown that mast cells can significantly influence multiple features of inflammatory or immune responses, through diverse effects that can either promote or, surprisingly, suppress, aspects of these responses. Through such functions, mast cells can significantly influence inflammation, tissue remodeling, host defense and homeostasis. (C) 2007 Japanese Society for Investigative Dermatology. Published by Elsevier Ireland Ltd. AR rights reserved.
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