期刊
JOURNAL OF DENTISTRY
卷 42, 期 9, 页码 1193-1201出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.jdent.2014.07.006
关键词
Antibacterial; Microcosm biofilm; Quaternary ammonium methacrylate; Bond strength; Lactic acid; Metabolic activity
资金
- NIH [R01 DE17974]
- Department of Endodontics, Prosthodontics and Operative Dentistry of University of Maryland School of Dentistry
- University of Maryland, Baltimore
Objectives: Demineralized lesions in tooth enamel around orthodontic brackets are caused by acids from cariogenic biofilm. This study aimed to develop a novel antibacterial orthodontic cement by incorporating a quaternary ammonium monomer dimethylaminododecyl methacrylate (DMADDM) into a commercial orthodontic cement, and to investigate the effects on microcosm biofilm response and enamel bond strength. Methods: DMADDM, a recently-synthetized antibacterial monomer, was incorporated into orthodontic cement at 0%, 1.5%, 3% and 5% mass fractions. Bond strength of brackets to enamel was measured. A microcosm biofilm model was used to measure metabolic activity, lactic acid production, and colony-forming units (CFU) on orthodontic cements. Results: Shear bond strength was not reduced at 3% DAMDDM (p > 0.1), but was slightly reduced at 5% DMADDM, compared to 0% DMADDM. Biofilm viability was substantially inhibited when in contact with orthodontic cement containing 3% DMADDM. Biofilm metabolic activity, lactic acid production, and CFU were much lower on orthodontic cement containing DMADDM than control cement (p < 0.05). Conclusions: Therefore, the novel antibacterial orthodontic cement containing 3% DMADDM inhibited oral biofilms without compromising the enamel bond strength, and is promising to reduce or eliminate demineralization in enamel around orthodontic brackets. Published by Elsevier Ltd.
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