4.8 Article

GlyTouCan 1.0-The international glycan structure repository

期刊

NUCLEIC ACIDS RESEARCH
卷 44, 期 D1, 页码 D1237-D1242

出版社

OXFORD UNIV PRESS
DOI: 10.1093/nar/gkv1041

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资金

  1. National Bioscience Database Center (NBDC)
  2. Japan Science and Technology Agency (JST)
  3. National Institute of General Medical Sciences [8P41GM103490]
  4. Biotechnology and Biological Sciences Research Council [BBF0083091, BB/K016164/1]
  5. Japan Science and Technology Agency (JST) [TG2608]
  6. Soka University
  7. BBSRC [BB/K016164/1] Funding Source: UKRI
  8. Biotechnology and Biological Sciences Research Council [BB/K016164/1] Funding Source: researchfish
  9. Grants-in-Aid for Scientific Research [26242088] Funding Source: KAKEN

向作者/读者索取更多资源

Glycans are known as the third major class of biopolymers, next to DNA and proteins. They cover the surfaces of many cells, serving as the 'face' of cells, whereby other biomolecules and viruses interact. The structure of glycans, however, differs greatly from DNA and proteins in that they are branched, as opposed to linear sequences of amino acids or nucleotides. Therefore, the storage of glycan information in databases, let alone their curation, has been a difficult problem. This has caused many duplicated efforts when integration is attempted between different databases, making an international repository for glycan structures, where unique accession numbers are assigned to every identified glycan structure, necessary. As such, an international team of developers and glycobiologists have collaborated to develop this repository, called GlyTouCan and is available at http://glytoucan.org/, to provide a centralized resource for depositing glycan structures, compositions and topologies, and to retrieve accession numbers for each of these registered entries. This will thus enable researchers to reference glycan structures simply by accession number, as opposed to by chemical structure, which has been a burden to integrate glycomics databases in the past.

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