The effect of casein phosphopeptide-amorphous calcium phosphate on erosive enamel and dentine wear by toothbrush abrasion

Objective: In addition to its role as a remineralizing agent in preventing dental caries, calcium product (CPP-ACP) delivered as a mousse (Tooth Mousse (R), TM) can reduce erosion of enamel and dentine. The aim of this study was to determine whether CPP-ACP could also reduce erosive tooth wear involving toothbrush abrasion. Methods: Flat, polished enamel and dentine specimens (n = 72) were subjected to 10 wear regimes, with each regime involving erosion in 0.3% citric acid (pH 3.2) for 10 min followed by toothbrush abrasion in a slurry of fluoride-free toothpaste and artificial saliva (1:3 ratio by weight) under a load of 2N for 200 cycles. The specimens were immersed in artificial saliva for 2 h between wear regimes. In the experimental group 1, TM (containing CPP-ACP) was applied at the beginning of each wear episode for 5 min whereas TM- (without CPP-ACP) was applied in the experimental group 2. No mousse was applied in the control group. Results: TM significantly reduced enamel wear (mean +/- S.E., 1.26 +/- 0.33 mu m in the experimental group 1 vs; 3.48 +/- 0.43 mu m in the control group) and dentine wear (2.16 +/- 0.89 mu m in the experimental group 1 vs 10.29 +/- 1.64 mu m in the control group), and dentine wear was significantly less in the experimental group 1 than in the experimental group 2 (5.75 +/- 0.98 mu m). Conclusion: The finding that TM reduced erosive tooth wear involving toothbrush abrasion, probably by remineralizing and lubricating eroded tooth surfaces, may have implications in the management of tooth wear. Crown Copyright (C) 2008 Published by Elsevier Ltd. All rights reserved.