期刊
JOURNAL OF DENTAL RESEARCH
卷 97, 期 13, 页码 1416-1423出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/0022034518798825
关键词
sex characteristics; bone and bones; neutrophils; osteoclasts; bacterial infections; chemokines
资金
- National Institutes of Health [1R21 DE027017-01]
- NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH [R21DE027017] Funding Source: NIH RePORTER
Sex is a biological variable that affects immune responses to bacterial and other types of infectious agents. Males and females are known to have differential oral bacterial disease burden in periodontal and endodontic disease. Understanding that there is a contribution from both sex and gender to these oral diseases, we discuss in this review recent sex-based findings that provide a pathobiological basis for differences observed between males and females. Sexual dimorphism of immune responses with respect to neutrophil trafficking and osteoclast differentiation and formation is presented as a plausible mechanism to explain the sexual differences. We also emphasize that sex, as a biological variable, should be considered in these types of oral immunologic studies.
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