期刊
JOURNAL OF DENTAL RESEARCH
卷 93, 期 7, 页码 698-703出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/0022034514536578
关键词
implant dentistry; biomaterial(s); biocompatibility; surface chemistry; wettability; osseointegration
资金
- Ministry of Education, Culture, Sports, Science and Technology of Japan [24592903]
- Grants-in-Aid for Scientific Research [24592903] Funding Source: KAKEN
Although the reported percentage of bone-implant contact is far lower than 100%, the cause of such low levels of bone formation has rarely been investigated. This study tested the negative biological effect of hydrocarbon deposition onto titanium surfaces, which has been reported to be inevitable. Osteogenic MC3T3-E1 cells were cultured on titanium disks on which the carbon concentration was experimentally regulated to achieve carbon/titanium (C/Ti) ratios of 0.3, 0.7, and 1.0. Initial cellular activities such as cell attachment and cell spreading were concentration-dependently suppressed by the amount of carbon on the titanium surface. The osteoblastic functions of alkaline phosphatase activity and calcium mineralization were also reduced by more than 40% on the C/Ti (1.0) surface. These results indicate that osteoblast activity is influenced by the degree of hydrocarbon contamination on titanium implants and suggest that hydrocarbon decomposition before implant placement may increase the biocompatibility of titanium.
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