期刊
JOURNAL OF DENTAL RESEARCH
卷 94, 期 1, 页码 209-218出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/0022034514557672
关键词
mesenchymal stem cells; deciduous teeth; cell therapy; telomerase; Fas ligand; Wnt pathway
资金
- US National Institute of Dental and Craniofacial Research (NIDCR), National Institutes of Health (NIH), Department of Health and Human Services [R01DE017449, R01DE019932]
- School of Stomatology, China Medical University, Shenyang, China
Stem cells from exfoliated deciduous teeth (SHED) possess multipotent differentiation and immunomodulatory properties. They have been used for orofacial bone regeneration and autoimmune disease treatment. In this study, we show that acetylsalicylic acid (ASA) treatment is able to significantly improve SHED-mediated osteogenic differentiation and immunomodulation. Mechanistically, ASA treatment upregulates the telomerase reverse transcriptase (TERT)/Wnt/beta-catenin cascade, leading to improvement of SHED-mediated bone regeneration, and also upregulates TERT/FASL signaling, leading to improvement of SHED-mediated T-cell apoptosis and ameliorating disease phenotypes in dextran sodium sulfate-induced colitis mice. These data indicate that ASA treatment is a practical approach to improving SHED-based cell therapy.
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