期刊
JOURNAL OF DENTAL RESEARCH
卷 92, 期 2, 页码 122-129出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/0022034512470954
关键词
amelogenesis; biomineralization; enamel; ion transport; pH homeostasis; endocytosis
资金
- US National Institutes of Health [DE013404, DE019629, DE022799, DK058563, DK077162]
- Melbourne Research Unit for Facial Disorders
Fully matured dental enamel is an architecturally and mechanically complex hydroxyapatite-based bioceramic devoid of most of the organic material that was essential in its making. Enamel formation is a staged process principally involving secretory and maturation stages, each associated with major changes in gene expression and cellular function. Cellular activities that define the maturation stage of amelogenesis include ion (e. g., calcium and phosphate) transport and storage, control of intracellular and extracellular pH (e. g., bicarbonate and hydrogen ion movements), and endocytosis. Recent studies on rodent amelogenesis have identified a multitude of gene products that appear to be linked to these cellular activities. This review describes the main cellular activities of these genes during the maturation stage of amelogenesis.
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