期刊
JOURNAL OF DENTAL RESEARCH
卷 90, 期 9, 页码 1070-1077出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/0022034511405330
关键词
developmental biology; cell-matrix interactions; microscopy; gene expression; cell signaling; tissue engineering
资金
- National Institute of Dental and Craniofacial Research
Salivary glands form during embryonic development by a complex process that creates compact, highly organized secretory organs with functions essential for oral health. The architecture of these glands is generated by branching morphogenesis, revealed by recent research to involve unexpectedly dynamic cell motility and novel regulatory pathways. Numerous growth factors, extracellular matrix molecules, gene regulatory pathways, and mechanical forces contribute to salivary gland morphogenesis, but local gene regulation and morphological changes appear to play particularly notable roles. Here we review these recent advances and their potential application to salivary gland tissue engineering.
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