期刊
JOURNAL OF DENTAL RESEARCH
卷 89, 期 4, 页码 378-383出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/0022034509360010
关键词
early childhood caries; S. mutans; Lactobacillus
资金
- USPHS [U54 DE-014264, DE-015847, DE-007151-18, DE-007327-07]
- National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA [K24 DE000419]
- Umea University, Sweden
Dental caries in pre-school children has significant public health and health disparity implications. To determine microbial risk markers for this infection, this study aimed to compare the microbiota of children with early childhood caries with that of caries-free children. Plaque samples from incisors, molars, and the tongue from 195 children attending pediatricians' offices were assayed by 74 DNA probes and by PCR to Streptococcus mutans. Caries-associated factors included visible plaque, child age, race, and snacking habits. Species were detected more frequently from tooth than tongue samples. Lactobacillus gasseri (p < 0.01), Lactobacillus fermentum, Lactobacillus vaginalis, and S. mutans with Streptococcus sobrinus (all p < 0.05) were positively associated with caries. By multifactorial analysis, the probiotic Lactobacillus acidophilus was negatively associated with caries. Prevotella nigrescens was the only species (p < 0.05) significantly associated with caries by the 'false discovery' rate. Analysis of the data suggests that selected Lactobacillus species, in addition to mutans streptococci, are risk markers for early childhood caries.
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