期刊
JOURNAL OF DENTAL RESEARCH
卷 89, 期 6, 页码 561-570出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/0022034510363682
关键词
leukemia; periodontitis; RTX toxin; LAP
资金
- National Institute of Dental and Craniofacial Research
- National Institute of Allergy and Infectious Diseases
- New Jersey Commission on Science and Technology
- Foundation of UMDNJ
Aggregatibacter actinomycetemcomitans is a Gram-negative bacterium that colonizes the human oral cavity and is the causative agent for localized aggressive periodontitis (LAP), an aggressive form of periodontal disease that occurs in adolescents. A. actinomycetemcomitans secretes a protein toxin, leukotoxin (LtxA), which helps the bacterium evade the host immune response during infection. LtxA is a membrane-active toxin that specifically targets white blood cells (WBCs). In this review, we discuss recent developments in this field, including the identification and characterization of genes and proteins involved in secretion, regulation of LtxA, biosynthesis, newly described activities of LtxA, and how LtxA may be used as a therapy for the treatment of diseases.
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