期刊
JOURNAL OF DENTAL RESEARCH
卷 88, 期 8, 页码 693-703出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/0022034509341629
关键词
Runx2; phosphorylation; ubiquitination; degradation; PTHrP
资金
- NIAMS [R01-AR051189, K02-AR052411, R01-AR054465, R21-AR53586, T32-AR053459]
- NIDDK
- Department of Defense [W81XWH-07-1-0160]
The Runx2 gene product is essential for mammalian bone development. In humans, Runx2 haplo-insufficiency results in cleidocranial dysplasia, a skeletal disorder characterized by bone and dental abnormalities. At the molecular level, Runx2 acts as a transcription factor for genes expressed in hypertrophic chondrocytes and osteoblasts. Runx2 gene expression and protein function are regulated on multiple levels, including transcription, translation, and post-translational modification. Furthermore, Runx2 is involved in numerous protein-protein interactions, most of which either activate or repress transcription of target genes. In this review, we discuss expression of Runx2 during development as well as the post-translational regulation of Runx2 through modification by phosphorylation, ubiquitination, and acetylation.
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