期刊
JOURNAL OF DENTAL RESEARCH
卷 88, 期 7, 页码 609-614出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/0022034509340008
关键词
osteoclasts; dental pulp; periodontal ligament; monocytes; RANKL
资金
- Department of Biochemistry, Endodontics and Operative Dentistry
- Pediatric Dentistry
- Matsumoto Dental University
- Ministry of Education, Culture, Sports, Science and Technology of Japan [20592192, 19390476, 19592375, 8390558]
- Grants-in-Aid for Scientific Research [19390476, 19592375, 20592192] Funding Source: KAKEN
Odontoclasts and cementoclasts are considered to play major roles in the internal resorption of dentin and the external resorption of tooth roots. In this study, we evaluated the osteoclast-inducing ability of human dental pulp and periodontal ligament cells, which are mesenchymal cells in dental tissues. These cells expressed RANKL and OPG mRNA constitutively. As osteoclast precursors, CD14(+) monocytes derived from human peripheral blood were isolated, and incubated together with human dental pulp or periodontal ligament cells. Both cell types spontaneously induced the differentiation of CD14(+) monocytes into osteoclasts without osteotropic factors. These results suggest that dental pulp and periodontal ligament cells are involved in regulating the differentiation and function of osteoclasts.
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