期刊
JOURNAL OF DENTAL RESEARCH
卷 88, 期 2, 页码 182-186出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/0022034508329693
关键词
Bdellovibrio; A. actinomycetemcomitans; probiotics; periodontitis
资金
- Catholic University of Leuven [OT07/057, PDM 07/220]
- Research Fund Flanders [G077209N, 1510109N]
Periodontitis is a polymicrobial infectious disease primarily associated with Gram-negative periodontopathogens. Bdellovibrio and like organisms are predatory bacteria that feed on Gram-negative bacteria. This study investigated whether predatory bacteria can attack Aggregatibacter actinomycetemcomitans. Therefore, A. actinomycetemcomitans was challenged with the predator Bdellovibrio bacteriovorus under conditions simulating the oral cavity. The reduction of planktonic A. actinomycetemcomitans was quantified via bacterial culture, and the development of predatory bacteria was monitored with quantitative real-time PCR. The destruction of A. actinomycetemcomitans biofilms by B. bacteriovorus was quantified by crystal violet staining and visualized by scanning electron microscopy. The in vitro results show that B. bacteriovorus can attack, prey on, and kill A. actinomycetemcomitans and suggest a potential for B. bacteriovorus as a living antibiotic for the prevention and treatment of periodontitis.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据