期刊
JOURNAL OF DENTAL RESEARCH
卷 87, 期 5, 页码 445-450出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/154405910808700508
关键词
minor salivary gland secretion; proteomics; oral; protein; saliva
资金
- NIDCR NIH HHS [R01 DE007652, R37 DE005672, R01 DE007652-20, R01 DE005672, R21 DE018132, DE18132, F31 DE005672, DE17788, DE05672, U01 DE017788, DE07652, R01 DE005672-27] Funding Source: Medline
Recent research efforts in oral biology have resulted in elucidation of the proteomes of major human salivary secretions and whole saliva. One might hypothesize that the proteome of minor gland secretions may show significantly different characteristics when compared with the proteomes of parotid or submandibular/sublingual secretions. To test this hypothesis, we conducted the first exploration into the proteome of minor salivary gland secretion. Minor gland secretion was obtained from healthy volunteers, and its components were subjected to liquid chromatography electrospray-ionization- tandem mass spectrometry. This led to the identification of 56 proteins, 12 of which had never been identified in any salivary secretion. The unique characteristics of the minor salivary gland secretion proteome are related to the types as well as the numbers of components present. The differences between salivary proteomes may be important with respect to specific oral functions.
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