期刊
JOURNAL OF DAIRY SCIENCE
卷 97, 期 2, 页码 651-658出版社
ELSEVIER SCIENCE INC
DOI: 10.3168/jds.2013-7153
关键词
lactoferrin; UV-induced skin damage; antiinflammatory effect; hairless mice
Lactoferrin (LF) is recognized as a host defensive glycoprotein, especially for newborn infants. The aim of this study was to investigate whether orally administered LF had protective activity against UV-induced skin damage in hairless mice. Transepidermal water loss and skin hydration were evaluated in nonirradiated mice, UVB-irradiated mice, and UVB-irradiated and LF-administered mice. Supplementation with LF (1,600 mg/kg per day) effectively suppressed the increase in transepidermal water loss, reduction in skin hydration, aberrant epidermal hyperplasia, and cell apoptosis induced by UV irradiation. Although no significant changes in superoxide dismutase-like activity or malondialdehyde levels were observed in the skin with both UV irradiation and LF administration, UV-stimulated IL-1 beta levels in the skin were significantly suppressed by the administration of LF. Oral supplementation with LF has the potential to reduce IL-1 beta levels and prevent UV-induced skin damage. Further studies are needed to elucidate the relationships between the antiinflammatory effects and skin protective function of LF.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据