期刊
JOURNAL OF CYSTIC FIBROSIS
卷 10, 期 -, 页码 S79-S81出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S1569-1993(11)60012-X
关键词
Pulmonary exacerbation; Cystic fibrosis; Outcome parameters; Definition; Consensus
资金
- European Union [LSHM-CT-2005-018932]
Pulmonary exacerbations represent a key outcome variable in clinical trials of cystic fibrosis (CF). As there is variation in the trigger for use of intravenous antibiotics compared to the use of oral antibiotics or new nebulised therapy for treatment of exacerbations, the consensus view is that use of intravenous antibiotics cannot be regarded as the key defining character for an exacerbation on its own. The consensus view is that the clinical need for additional treatment as indicated by a recent change in clinical parameters provides the best definition of an exacerbation. Which parameters to include as well as the problems associated with the use of scoring systems and symptom clusters are being discussed. (C) 2011 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved.
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