期刊
出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.nimb.2015.05.036
关键词
CRDS; Spectroscopy; Carbon-14
类别
资金
- NCRR NIH HHS [P41 RR013461] Funding Source: Medline
- NIGMS NIH HHS [R21 GM111242, P41 GM103483] Funding Source: Medline
Accelerator Mass Spectrometry CAMS) is the most sensitive method for quantitation of C-14 in biological samples. This technology has been used in a variety of low dose, human health related studies over the last 20 years when very high sensitivity was needed. AMS helped pioneer these scientific methods, but its expensive facilities and requirements for highly trained technical staff have limited their proliferation. Quantification of C-14 by cavity ring-down spectroscopy (CRDS) offers an approach that eliminates many of the shortcomings of an accelerator-based system and would supplement the use of AMS in biomedical research. Our initial prototype, using a non-ideal wavelength laser and under suboptimal experimental conditions, has a 3.5-modern, 1-sigma precision for detection of milligram-sized, carbon-14-elevated samples. These results demonstrate proof of principle and provided a starting point for the development of a spectrometer capable of biologically relevant sensitivities. Published by Elsevier B.V.
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