期刊
JOURNAL OF CUTANEOUS PATHOLOGY
卷 40, 期 3, 页码 310-316出版社
WILEY-BLACKWELL
DOI: 10.1111/cup.12066
关键词
gamma delta T-cell; gamma delta T-cell lymphoma; cutaneous lymphoma; extranodal natural killer/T-cell lymphoma; peripheral T-cell lymphoma; Taiwan
Primary cutaneous gamma delta T-cell lymphoma and extranodal natural killer (NK)/T-cell lymphoma (ENKTL), nasal type are two distinct lymphoma entities in the World Health Organization (WHO) classification. We report the case of an aggressive cutaneous lymphoma of gamma delta T-cell origin showing overlapping features of both lymphomas. A 78-year-old female presented with confluent erythematous plaques with ulcerations over her right thigh. Microscopically, section of the skin showed a diffuse dermal and subcutaneous lymphocytic infiltration with tumor necrosis and angioinvasion. The medium-to large-sized tumor cells expressed CD3, CD8, cytotoxic molecules and T-cell receptor (TCR)-gamma but not CD4, CD20, CD30, CD56 or beta F1. In situ hybridization for Epstein-Barr virus-encoded mRNA (EBER) was diffusely positive. Polymerase chain reaction-based clonality assay showed a clonal TCR-gamma chain gene rearrangement. The features compatible with gamma delta T-cell lymphoma include dermal and subcutaneous involvements, cytotoxic phenotype, expression of TCR-gamma, as well as an aggressive course. On the other hand, the diffuse EBER positivity, angioinvasion, tumor necrosis and cytotoxic phenotype may also fit in the diagnosis of an ENKTL of T-cell lineage. We review the literature on EBER-positive gamma delta T-cell lymphoma and discuss the diagnostic dilemma using the current WHO classification system.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据