期刊
JOURNAL OF CROHNS & COLITIS
卷 6, 期 9, 页码 913-923出版社
OXFORD UNIV PRESS
DOI: 10.1016/j.crohns.2012.02.010
关键词
Crohn's disease; Ulcerative colitis; TREM-1; TLR; Inflammatory bowel disease
资金
- Swiss National Science Foundation [3200B0_122560, 33CS30_134274]
- Swiss National Science Foundation (SNF) [33CS30_134274] Funding Source: Swiss National Science Foundation (SNF)
Background & aims: Triggering receptor expressed on myeloid cells-1 (TREM-1) is a potent amplifier of pro-inflammatory responses. We have previously demonstrated a substantial increase in TREM-1-expressing macrophages in the inflamed intestinal mucosa of patients with inflammatory bowel diseases (IBD). TREM-1 is also produced as a soluble receptor (sTREM-1). Here, we aimed to determine whether serum sTREM-1 could be used as a surrogate marker of disease activity in patients with IBD. Methods: Intestinal biopsies and concurrently collected sera from patients with Crohn's disease (CD) and Ulcerative colitis (UC) enrolled in the Swiss IBD cohort study were analyzed for intestinal TREM-1 mRNA and serum sTREM-1 expression. TREM-1 mRNA and sTREM-1 were correlated with the endoscopically determined disease activity. Serum sTREM-1 and TREM-1 mRNA expression levels were further determined in sera and colonic tissues collected at various time-points post disease induction in an experimental mouse model of colitis and correlated with disease activity. Results: Expression of TREM-1 mRNA was upregulated in intestinal biopsies from patients with active disease but not in patients with quiescent disease. Serum sTREM-1 was elevated in IBD patients compared to normal controls. No substantial differences in sTREM-1 expression levels were found in patients with active versus quiescent disease. In colitic mice, colonic TREM-1 mRNA and serum sTREM-1 were also upregulated. While colonic TREM-1 nnRNA expression levels correlated with disease activity, augmented serum sTREM-1 in fact associated with a milder course of disease. Conclusions: Analysis of sTREM-1 as a surrogate marker of disease activity in patients with IBD warrants caution. (C) 2012 European Crohn's and Colitis Organisation. Published by Elsevier B.V. All rights reserved.
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